Apomorphine for ED: FDA Status and Which Products Contain It

Below: what apomorphine does, what the studies found for ED, which products contain it, their prices, and the safety points from the label. We give no doses. A prescriber decides whether any of this fits you.

What apomorphine is

Apomorphine is a dopamine drug. Dopamine is a brain chemical tied to movement, reward and sexual arousal. The Apokyn label calls it "a non-ergoline dopamine agonist", which means it switches on dopamine receptors the way dopamine itself does (Apokyn label). Despite the name, it contains no morphine and is not an opioid.

ED pills such as sildenafil and tadalafil work in a different place. They act on blood vessels in the penis. Apomorphine acts in the brain, on the arousal signal that starts an erection. That is why sellers pair it with sildenafil or tadalafil: one targets the brain, the other the blood flow.

Apomorphine for men with ED: what the studies found

Apomorphine was studied for ED as a tablet that melts under the tongue. A 2020 review pooled nine trials that compared it with a dummy pill. It found that "All the studies found that apomorphine was better than placebo (6-27% more successful intercourse attempts than with placebo)" (Guillén et al., Archives of Sexual Behavior, PubMed, read 14 November 2026). A placebo is a dummy pill with no drug in it.

The same review found a cost in side effects: "Discontinuation of treatment due to adverse events was higher for apomorphine, particularly for higher doses" (PubMed 32964351). In plain words, more men stopped because of side effects.

How does it compare with standard ED pills? An earlier review by UK urologists was direct: "it is not as effective as PDE5-I in the treatment of ED" (Mohee et al., Expert Opinion on Drug Metabolism and Toxicology, PubMed). PDE5-I means PDE5 inhibitors, the class that includes sildenafil and tadalafil. The same review added that "Apomorphine is not a first-line treatment option for patients with ED".

So the evidence is real but modest. Apomorphine alone beat a dummy pill, and it trailed the standard ED pills. No trial we found tested the compounded mixes sold online, where apomorphine sits next to two or three other drugs.

Which ED products contain apomorphine

Every apomorphine ED product we found online is compounded. That means a pharmacy mixes it to order. The FDA says "Compounded drugs are not FDA-approved. This means that FDA does not verify the safety, effectiveness or quality of compounded drugs before they are marketed" (FDA: compounding questions and answers, read 14 November 2026).

Strut Health's own page adds the plain truth: "Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA" (Strut Health). Each of these sellers asks a licensed clinician to review your health answers first.

Apomorphine and oxytocin in ED tablets

SuperStrut and BlueChew GOLD add oxytocin as well. Oxytocin is a hormone the body releases during touch and orgasm. BlueChew describes it as supporting libido. We found no trial of oxytocin in these mixed tablets; our guide to ED tablet add-ins covers what the oxytocin research shows. Our guide to compounded ED medication explains how these mixes differ from single generic pills.

The real choice is a single FDA-approved pill or a compounded mix. The mix puts several drugs in one tablet. That can suit men who want one product. It also means more side effects can stack, and no FDA review of the finished tablet.

Is apomorphine safe?

The safety facts come from the Parkinson's label, since no ED label exists. Doses in Parkinson's injections differ from the amounts in ED tablets, so treat these as warnings to raise with a prescriber, not a prediction.

• Nausea and drowsiness. The label lists "yawning, drowsiness/somnolence" and "nausea and/or vomiting" among the most common side effects. It also warns that "Falling asleep during activities of daily living, and daytime somnolence may occur" (Apokyn label).
• Low blood pressure and fainting. The label warns that fainting and drops in blood pressure can happen. It also says "Patients should avoid alcohol when using APOKYN".
• Anti-nausea drugs. The label says "Concomitant use of APOKYN with 5HT 3 antagonists" such as ondansetron is not allowed. In plain words, you must not take it with certain anti-nausea medicines.

The mixed ED tablets also contain sildenafil, tadalafil or vardenafil. So the ED pill rules apply too. Never take them with nitrates, the chest pain drugs such as nitroglycerin. Our ED pill side effects guide quotes those labels.

Who sells apomorphine for ED, and the FDA-approved options

Only licensed online programs sell these tablets, after a clinician reviews your health answers. A site that sells apomorphine with no prescription skips that step. The FDA's BeSafeRx list names that as the first warning sign.

If you want an FDA-approved pill instead, generic sildenafil and tadalafil are the cheapest route:

Prices checked November 14, 2026. Payment never moves a rank; see how we rank programs.