Ro Sparks Side Effects and Ingredients: What Ro and the Labels Say
Ro Sparks side effects and ingredients from Ro's safety page and the FDA labels for sildenafil and tadalafil, who should not use it and approved options priced.
By Julian Caraulani · Last updated
SafetyReviewed by Dr. A. Goher, MBBS
- FDA-approved and compounded
- LegitScript seal ID shown
- 49 states (not AR)
Below: what is in Sparks, what each label reports, the warnings Ro gives, whether it works, and approved options with prices. For cost per dose next to BlueChew and Hims, see our Ro Sparks review.
What is Ro Sparks?
Sparks is Ro's two-in-one ED product. It is a small lozenge that dissolves under the tongue. Ro says Sparks "contains the active ingredients in Viagra (sildenafil) and Cialis (tadalafil) into a single sublingual drop" (Ro Sparks, read 14 November 2026). Sublingual means under the tongue.
A Ro-affiliated provider reviews an online visit first. If Sparks is prescribed, a pharmacy makes it and Ro ships it. Ro sells it in plans of 4 to 10 doses a month.
| Plan | What it is | Per dose | Per month | Billing | Read |
|---|---|---|---|---|---|
| Ro Sparks (compounded sildenafil + tadalafil), 4 doses Compounded sublingual tablet. Also 6, 8 and 10 dose plans at the same per-dose price. | Compounded, not FDA-approved | $12 per dose | $48 | monthly | November 7, 2026 |
Ro Sparks ingredients
| Ingredient | What it does | FDA-approved form |
|---|---|---|
| Sildenafil | Raises blood flow to the penis when you are aroused; taken before sex | Viagra and generic sildenafil tablets |
| Tadalafil | Works the same way and lasts much longer, up to 36 hours | Cialis and generic tadalafil tablets |
Sources: Viagra label and Cialis label, read 14 November 2026.
Ro's safety page lists two more things to know about. Sparks contains the food dyes Yellow No. 5 and Red No. 40. Ro also says not to use Sparks with a coconut allergy, "since coconut oil is used during processing" (Ro Sparks safety information).
- FDA-approved and compounded
- LegitScript seal ID shown
- 49 states (not AR)
Is Ro Sparks FDA approved?
No. Ro says so on its safety page: "Compounded drugs are permitted to be prescribed under federal law but are not FDA-approved and do not undergo FDA safety, effectiveness, or manufacturing review." (Ro Sparks safety information)
Compounded means a pharmacy mixes the medicine to order. The FDA puts it the same way: "Compounded drugs are not FDA-approved." (FDA: compounding questions and answers, read 14 November 2026) Both drugs inside are approved as separate pills. The two-drug lozenge is not.
Ro Sparks side effects: what the labels report
Ro gives one list for Sparks. The approved labels give trial rates for each drug alone. Each figure compares men on the drug with men on a placebo, a dummy pill. Nobody has published rates for the two drugs together in one lozenge.
| Side effect | Sildenafil (Viagra) | Tadalafil (Cialis) |
|---|---|---|
| Headache | 16% vs 4% on dummy pill | 15% vs 5% |
| Flushing | 10% vs 1% | 3% vs 1% |
| Indigestion | 7% vs 2% | 10% vs 1% |
| Stuffy nose | 4% vs 2% | 3% vs 1% |
| Back pain | 2% vs 2% | 6% vs 3% |
Sources: Viagra label and Cialis label. Read the first row this way: about 16 in 100 men on sildenafil had a headache, against 4 in 100 on the dummy pill.
Is Ro Sparks safe? The warnings Ro gives
Ro's safety page is detailed. These are the points that matter most.
Nitrates. Do not use Sparks with nitrate heart medicines such as nitroglycerin. Ro warns that the combination "can cause dangerously low blood pressure."
Two ED drugs in one dose. This is the warning that is special to Sparks. Ro says: "This compounded medication contains two prescription PDE-5 inhibitors, sildenafil and tadalafil." It tells users to watch for signs of very low blood pressure, "such as dizziness, fainting, or prolonged erection." (Ro Sparks safety information) Do not add another ED pill on the same day.
Alcohol and blood pressure pills. Ro warns that heavy drinking, alpha-blockers and other blood pressure drugs can add to the drop in blood pressure. Tell the provider about every medicine you take.
Long erections, sight and hearing. Get emergency care for an erection lasting over four hours. Stop and get help for sudden loss of vision in one or both eyes, or sudden hearing loss.
Heart health. Ro says ED medicine should not be used by men who have been told sex is not safe for their heart.
Does Ro Sparks work?
Sildenafil and tadalafil each work for most men with ED in their own trials. For the two-drug lozenge, we found no published trial. So the honest answer is that the drugs inside have strong evidence, and the mix has none of its own. Ro's onset claims are covered in our Ro Sparks review.
FDA-approved options and their prices
Ro sells the approved generics too. Generic sildenafil starts at $4 a dose at Ro, and generic tadalafil at $11 a dose. Elsewhere, generic sildenafil starts at $1.60 a dose at Strut Health, and daily generic tadalafil at $1.80 a dose at Rex MD, both with the visit included.
Our sildenafil vs tadalafil guide explains how the two drugs differ. The ED pill side effects guide compares the labels in more depth. For all of Ro's plans, see our Ro review.
Questions
FAQ
What are the Ro Sparks side effects and ingredients?
Ro Sparks holds sildenafil and tadalafil, the drugs in Viagra and Cialis, in one compounded lozenge. Ro lists headache, dizziness, indigestion, back pain, muscle pain, stuffy nose, flushing and limb pain as the most common side effects. It also contains two food dyes and is made with coconut oil.
What is Ro Sparks?
Ro Sparks is a compounded ED lozenge from Ro that dissolves under the tongue. It combines sildenafil and tadalafil in one dose. A Ro-affiliated provider must prescribe it after an online visit. Ro sells it in plans of 4 to 10 doses a month at $12 a dose.
Is Ro Sparks safe?
Ro calls Sparks a compounded drug that is not FDA-approved. Each drug inside is approved and well studied. Ro warns that two ED drugs in one dose raise the risk of low blood pressure. Men on nitrates must not use it, and every other medicine should be shared with the provider.
Does Ro Sparks really work?
No published trial has tested the Sparks lozenge itself. Sildenafil and tadalafil each work for most men with ED as approved pills. Whether the two together work better than one alone has not been shown in a study we could find, read 14 November 2026.
Can I take Ro Sparks with alcohol?
Ro's safety page warns that heavy drinking with tadalafil can raise the risk of a sudden drop in blood pressure. Light drinking is a question for the provider. Signs of low blood pressure include dizziness, lightheadedness and fainting.
Is Ro Sparks cheaper than generic pills?
No. Sparks costs $12 a dose at Ro, against $4 for Ro's generic sildenafil, read 7 November 2026. Compare every program on our ED price table or see the best men's health programs. For every ED program side by side, see our ED cost table.
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