Sildenafil and Tadalafil Together: What Both Labels Say

Below: what each label says, what the one small trial found, which combination products exist and what they cost, and the cheaper single-drug options. We give no doses. Only a prescriber who knows your health should decide on a combination.

Can you take Cialis and Viagra together? What the labels say

Cialis is the brand of tadalafil. Viagra is the brand of sildenafil. Both belong to the same class of drug, PDE5 inhibitors. Each label has a section on combining it with another ED drug.

The Viagra label, section 5.7, says "The safety and efficacy of combinations of VIAGRA with other PDE5 Inhibitors" and other ED treatments "have not been studied" (Viagra label). Safety and efficacy means whether it is safe and how well it works. The section ends: "Therefore, the use of such combinations is not recommended."

The Cialis label, section 5.11, says the same in its own words. "The safety and efficacy of combinations of CIALIS and other PDE5 inhibitors or treatments for erectile dysfunction have not been studied." It then tells doctors to "Inform patients not to take CIALIS with other PDE5 inhibitors, including ADCIRCA" (DailyMed: Cialis label, read 14 November 2026). Adcirca is tadalafil sold for a lung blood pressure condition.

So the answer from both makers is clear. Do not stack one ED pill on top of another unless a prescriber has chosen that on purpose.

Why combining them is a concern

Both drugs widen blood vessels. Each one on its own can lower blood pressure a little. Taken together, the drop can add up. That is the reason the Viagra label gives: such combinations "may further lower blood pressure".

The risk climbs with other drugs that also lower blood pressure. These include alpha-blockers for the prostate, such as tamsulosin, and many blood pressure pills. Nitrates, the chest pain drugs such as nitroglycerin, must never be taken with any ED pill. Our ED pill side effects guide lists those drug clashes from the labels.

There is also the simple point of stacking side effects. Headache, flushing, upset stomach and back pain are common with both drugs. Two drugs can mean more of each.

Tadalafil and sildenafil: what the one trial found

We found one controlled trial of the two used together. Doctors in China gave 180 men either daily tadalafil alone, or daily tadalafil plus sildenafil when needed. They reported that "There was no difference between two groups in the incidence of adverse events" (Cui et al., Andrologia, PubMed, read 14 November 2026). Adverse events means side effects and other problems.

The authors concluded that "combined medication can better improve erectile function, especially for patients with severe ED" (PubMed 24387078). That is one small study at one hospital. The men were checked by their doctors throughout. It does not change what either label says, and it did not test the compounded mixed tablets sold online.

Viagra and Cialis combo products sold online

Several programs sell one tablet that holds both drugs, sometimes with other drugs added. Every one of these is compounded. That means a pharmacy mixes it to order, and it is not FDA-approved. The FDA does not review a compounded product before it is sold.

MangoRx describes Mango Max as "Prescription tadalafil and sildenafil with oxytocin and naltrexone in one mango-flavored dissolving tablet" (MangoRx). Our Ro Sparks review and Hims Hard Mints guide cover two of these products in detail.

Why would a prescriber choose a combination at all? Sellers pitch it as the fast start of sildenafil plus the long window of tadalafil. That is a marketing claim, not a label claim. A clinician who prescribes it is making a choice outside both labels, and should know every other drug you take.

Single-drug options, and what they cost

For most men, one drug alone does the job. Generic sildenafil and generic tadalafil are FDA-approved and cost less per dose than any combination tablet above.

Prices checked November 14, 2026. If one drug is not working well enough, a common next step is a talk with the prescriber about the dose, the timing, or switching drugs. Tadalafil taken daily is another route a prescriber may raise; our daily tadalafil cost guide prices it. Our sildenafil vs tadalafil guide compares the two side by side.

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